What comes to our minds when we utter these two words together ’ketones and Diabetes’. The most popular and rightly so for its life-threatening outcome is ‘Diabetic ketoacidosis’. But there is something more to it – something useful. Ketones are a good alternative source of energy in the human body, especially for people with diabetes, who otherwise find it difficult to metabolize the carbohydrates.
If we can achieve a moderate level of ketogenesis without allowing its toxic acidotic damages to occur, it can greatly benefit the basic metabolism of people with diabetes. Then comes the next question ‘how do we achieve a moderate ketogenic environment?’ This review will discuss the basic pathophysiology of ketone metabolism in the body, ketogenesis produced by SGLT2 inhibitors and the swinging of pendulum of evidence related to ketogenic diets. Ketones Physiology and Pathology Technically…
