Differentiating rheumatic disorders can be difficult and may have major consequences if not diagnosed and managed efficiently. Therefore, primary care providers should be prepared to recognize possible rheumatic diseases and to provide a rapid referral to a rheumatologist. This article provides a quick guide on diagnostic strategies for early and better diagnosis of rheumatic diseases. Basic Principles The differential diagnosis of rheumatic disease may seem complex at first but can be subdivided into 3 discernible categories: Inflammatory arthritis Non-inflammatory arthritis Non-articular pain If the swelling is associated with inflammation, inflammatory arthritis should be suspected.

When there is no evidence of joint inflammation, non-inflammatory arthritis is much more likely the underlying condition. Laboratory findings, when to order? Synovial fluid analysis is the most preferred…