Leflunomide is an isoxazole derivative used for the treatment of rheumatoid arthritis (RA). This drug is structurally unrelated to other immunomodulatory disease modifying antirheumatoid drugs and offers a unique mechanism for the therapy of RA. Additionally, Leflunomide is also used in juvenile polyarthritis. refractory dermatomyositis, and systemic lupus erythematosus, but it has not been effective in ankylosing spondylitis. This article covers the most important aspect of the drug its “Side effects” and things to monitor while prescribing the drug.
Leflunomide (LEF) is an oral drug and rapidly absorbs in the gastrointestinal tract. Once LEF is absorbed it is converted into its active form. The major action of teriflunomide at the given dose for rheumatoid arthritis is inhibition of the synthesis of a pyrimidine known as ribonucleotide uridine monophosphate pyrimidine. ADVERSE EFFECTS…
