This article provides an overview of the study conducted to determine if there is a link between airborne particulate matter exposure and pathological brain aging in older women. Older women staying in different regions and not having neurodegenerative disorders were included in the study. The researchers followed the same experimental set up in the mouse models. Particulate matter (ambient fine particles) with diameter < 2.5µm from traffic emission are a major source of urban pollution, accounting globally for 25% ambient PM.
Epidemiologic studies indicate the association between cognitive deficits with PM exposure in elderly. Rodent models also indicate long-term neurotoxic effects of air pollutants including memory impairment and selective atrophy, decreased glutamate receptor subunit GluR1, and increased endogenous soluble Aβ. This study was designed to determine if there is a link…
