Autosomal dominant polycystic kidney disease (ADPKD), is a systemic disorder that accounts for 7%-15% of patients on renal replacement therapy. It mainly involves kidney but cysts can also occur in other organs such as the liver, pancreas, arachnoid membrane and seminal vesicles. This article outlines some of the updated clinical management strategies for polycystic kidney disease. ADPKD is generally a late-onset multi-system disorder characterized by bilateral renal cysts, but cysts can also occur in other organs such as the liver, pancreas and arachnoid membrane.
About 50% of individuals with ADPKD have end-stage renal disease (ESRD) by the age 60 years. As a result management of this condition is imperative. Pathological considerations Studies report that about 85%-90% of ADPKD cases, results from a mutation in the PKD1 gene, and the other 10%-15% of cases are accounted for by…
