The chronic kidney disorder (CKD) causes network alternations in minerals and skeletal disorders that contribute to the cardiovascular calcification and mortality. However, clinical trials have failed to support this causality. Recent studies indicate novel pathways for therapeutic interventions.This article summarizes recent studies performed in the clinical management of chronic kidney diseases-bone mineral disorders .
Kidney Disease Improving Global Outcomes (KDIGO) has issued that the mineral and skeletal disorders caused by CKD are critical contributors to the high cardiovascular morbidity and mortality seen in patients. Although the alterations occur in the complex physiological network connecting bone and the cardiovascular system, clinical trials are yet to prove this link. Following are some of the altered mineral metabolism: FGF-23 elevation Decreasing Calcitriol Increasing…
