Recurrent Vulvovaginal candidiasis is defined as four or more episodes of symptomatic infection within one year. Studies have shown that recurrent infection is due to relapse from a persistent vaginal reservoir of organisms or endogenous reinfection with the identical strain of susceptible C. albicans. Sometimes the infection is due to different Candida species. Recurrence is said to have occur in 5 % of cases.
Recurrent Vulvovaginal candidiasis has been associated with decreased in vivo concentration of mannose binding lectin (MBL) and increased concentration of interleukin-4. Two specific gene polymorphisms, variants in the MBL and interleukin-4 alleles, can account for this finding in some women. The prevalence of a variant MLB gene is higher in women with recurrent Vulvovaginal candidiasis than in controls without candidiasis. Risk factors: The risk factors (like Diabetes mellitus,…
