There is a lack of effective drugs for atrial fibrillation (AF), thereby contributing to significant morbidity and mortality in patients with AF. AF increases the risk of stroke, heart failure , and dementia. Moreover, AF increases the chances of annual hospitalization by 30%, thus posing a huge financial burden to the healthcare system. Using transcriptomics-based network analysis, researchers predicted the use of metformin , the gold standard anti-diabetic drug, as a repurposed drug for treating AF.
The study demonstrates that network proximity analysis of differentially expressed genes from atrial tissue to drug targets can help identify repurposed drugs for treating AF. ##Reference## Lal et al. Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation. Cell Reports Medicine 3, 100749, October, 2022.## Do you think metformin…
