The MIST Therapy system (Celleration) aims to promote wound healing in chronic, 'hard-to-heal' wounds and acute wounds, by delivering low-energy, low-intensity ultrasound to the wound bed through a continuous saline mist. The mist is claimed to transmit the ultrasonic energy to the wound bed, to activate healing by the removal of slough, exudate, and bacteria, and to stimulate tissue regeneration. The MIST Therapy system comprises a generator, a single-use applicator, and a sterile saline bottle. Wound surface area is measured and entered into the MIST Therapy system, which then calculates the appropriate treatment time.

When the applicator and saline bottle are connected, the ultrasound system is activated and a continuous mist is delivered to the wound bed using a handheld applicator. The distance between the applicator and the wound bed is 0.5–1.5 cm. Once the treatment is complete,…