Mostly occurring in the patients after kidney transplantation, Monoclonal Gammopathy of Renal Significance (MGRS) can significantly damage renal functions. Since the past decade, a significant number of MGRS cases have been reported. This article outlines the pathological condition and diagnosis of MGRS. How was the term MGRS coined? Monoclonal Gammopathy of Undetermined Significance (MGUS) is considered as a precursor of multiple myeloma onset and progression.
However, the medical fraternity was previously unaware of the relevant clinical significance of monoclonal gammopathies related to end-organ damage. Since past decade, a growing number of renal complication cases related to monoclonal gammopathies have been reported. Although renal complications are related to multiple myeloma, these particular cases of kidney damage were relevant to MGUS instead of features of myeloma. This lead…
