Oral cavity squamous cell carcinoma (OC-SCC) is currently a major global health issue and most common malignancy of the head and neck. However, latest evidence has shown a dramatic increase in the incidence of oropharyngeal squamous cell carcinoma (OP-SCC). This article presents the major risk factors for OC-SCC and OP-SCC. The oral cavity and oropharynx are two different regions anatomically, broadering each other, however, do not overlap.

The anatomic subsites of the oral cavity include the labial mucosa, buccal mucosa, floor of mouth, alveolar ridge and gingiva, anterior two-thirds of the tongue, hard palate, and retromolar trigone. The orods, valleculae, and posterior pharyngeal wall. Prevalence and mortality According to GLOBOCAN, in 2012, the worldwide prevalence of lip/oral cavity cancer were approximately 3,00,373 and, 1,42,387 new cases of other pharyngeal cancer were…