New Blood Test To Distinguish Celiac Disease Vs Gluten Sensitivity

The researchers in the USA have devised a new diagnostic test that can effectively distinguish patients with celiac disease (CD) form non-celiac gluten sensitivity (NCGS). This novel blood test measures circulating cytokines in the plasma within 6 hours of consuming gluten-containing diet. The investigators reported that oral-gluten challenge leads to dramatic increase in interleukin (IL)-8 , IL-10 , and most predominantly IL-2 in CD patients. Surprisingly, no such measurable immune response was reported in patients with NCGS after gluten challenge.

However, NCGS patients developed classical symptoms after consumptions of FODMAP carbohydrates especially fructans. The immune response to gluten challenge in CD patients was attributed to T-cell activation. It is known that gluten stimulates T cells within 2-4 hours. However, lack any interleukin spike in NCGS patient after gluten challenge…