A direct "aquarium-to-bedside" approach could be considered in a study that describes taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease. Dravet syndrome: A catastrophic childhood epilepsy characterized by Early-onset seizures Delayed language Motor development Sleep disturbances Anxiety-like behaviour Severe cognitive deficit An increased risk of fatality. It is primarily caused by de novo mutations of the SCN1A gene encoding a neuronal voltage-activated sodium channel.
Primary hypothesis : Because antihistamines are known to aggravate pediatric epilepsies and zebrafish H1 shows poor homology with human, the study hypothesized that clemizole does not exert antiepileptic activity via an anti-histaminergic mechanism of action. Study design and outcomes Zebrafish with a mutation in the…
