Acne is commonly treated with antibiotics and other compounds like retinoids and benzoyl peroxide. However, the increasing prevalence of antibiotic resistance demands alternatives to treat acne. Spironolactone, a potassium-sparing diuretic and anti-androgenic drug, is one such non-antibiotic treatment that has been prescribed to treat severe acne. However, there is a paucity of evidence from clinical trials suggesting the efficiency of spironolactone in treating acne, with the largest trial to date including only 34 participants.
In a recent study, researchers evaluated spironolactone’s efficiency on 410 women (Mean age – 29.2 years) with acne. It was found that spironolactone improved Acne-Specific Quality of Life and ‘participant self-assessed improvement’ scores at weeks 12 and 24 compared to placebo . The results were better at week 24 than week 12. In addition, Investigator’s…
