Primary central nervous system marginal zone lymphoma (CNS-MZL) is a rare lymphoma that mainly presents in the dura (69-80% of cases). Though a definite treatment regimen has not been established for CNS-MZL, many retrospective trials have reported the success of radiation therapy. Unfortunately, evidence supporting the efficacy of low-dose radiation therapy is inconclusive, and the optimal radiation field for ill-defined lesions is not known.
However, the International Lymphoma Radiation Oncology Group (ILROG) recommends 30–36 Gy for primary well-defined dural lesions as focal therapy. This article summarizes a case report that discusses the successful treatment of ill-defined central nervous system marginal zone lymphoma (CNS-MZL) using low-dose whole-brain radiation therapy (WBRT) instead of the ILROG recommended higher dose focal radiation therapy for well-defined dural lesions.…
