Paget's disease is a chronic bone disorder often causes no symptoms and leads to other medical conditions. Treatment goals include administration of medications that slow the rate of bone turnover, decreasing the activity of Paget's disease. Paget's disease can cause pain in the bones or joints, headaches and hearing loss, pressure on nerves, increased head size, bowing of limb, or curvature of spine.
Indications for drug treatment of Paget disease Bone pain, fatigue fracture, skull/spine fracture, radiculopathy, osteolytic lesions, bony deformities, weight-bearing bone involvement, compression of spinal cord and nerve roots, bone compression of the eighth cranial or optic nerve Hypercalcemia, serum alkaline phosphatase or urine hydroxyproline levels greater than twice the upper limit of the reference range; immobilization. If the disease affects the area around any joint then the…
