Transplantation of pancreatic islets helps type I diabetes patients attain exogenous insulin independence for several years. However, the transplanted islets need a continuous supply of blood, oxygen, and nutrition to survive. In addition, the immune response at the transplantation site can also have a negative impact on the transplanted islets.
Therefore, researchers are currently examining several potential transplantation sites, including the anterior eye chamber, bone marrow, subcutaneous space, omentum, muscles, and spleen, to extend the survival of the transplanted islets. The optimal transplantation sites should be potentially immune-privileged, vascularized and innervated, and easily accessible during surgery. Source : Frontiers in Endocrinology, The New England Journal of Medicine, and The Journal of Clinical Investigation ##Disclaimer## The content provided on Docplexus is…
