Treating recurrent urinary tract infections (UTIs) with a neurogenic bladder (NGB) in children is a challenge owing to the emergence of resistant extended-spectrum beta-lactamase organisms. A recent study has revealed that intravesical gentamicin, compared to oral antibiotic prophylaxis, effectively reduces the incidence of UTI and other asymptomatic urinary infections in children without risking bacterial resistance. Method Seventeen children with neurogenic bladder were evaluated retrospectively. Intravesical gentamicin administration followed an initial oral antibiotic prophylaxis.
A matched comparison of the rate of UTIs, the identified pathogens, and their antibiotic susceptibility between the two therapies was made. Intravesical gentamicin achieved a 38% reduction in UTI incidence and a 75% reduction in other asymptomatic urinary infections. However, one major limitation of the…
