Atopic dermatitis (AD) is one of the most common pediatric disorders, affecting 15% to 25% of children and 4% to 7% of adults. The condition usually manifests within the first 5 years of life, and when encountered in adults, the disease has been generally shown to be present for decades. Thus, understanding molecular circuits of evolving AD skin lesions in children and their differences and similarities from those of adults is critical for prioritizing pathogenesis-based AD therapies in children.
In adults AD skin, immune fingerprinting has been linked to more than 1 cytokine pathway, including possible roles for TH2, TH22 and TH17/IL-23 activation. Limited knowledge exists in literature in the relation to pediatric AD, and is largely limited to its correlation with a few serum biomarkers IL-31, CCL17, CCL22, CCL27, eosinophils, and IgE and mRNA expression of TH2/TH1 markers. In a…
