Cognitive, olfactory, and reproductive deficits are characteristic of patients with Down syndrome (DS) or trisomy 21. However, currently, no definite treatment for the cognitive and olfactory deficits in DS exists. Researchers have investigated the therapeutic potential of gonadotropin-releasing hormone (GnRH) replacement in restoring cognition and olfaction in human adults with DS . Rationale GnRH is secreted physiologically in a pulsatile manner and controls reproduction in all mammals.
In addition, it is involved in cognition and olfaction. Therefore, the characteristic progressive deficits in DS may be associated with an impaired GnRH system and, perhaps, can be reversed with targeted therapeutic GnRH alteration. The mice study The human study A pilot study on human adults with DS was conducted based on the findings of the mice study to investigate the therapeutic effects of…
