Researchers at the Sun Yat-Sen University, China, have found that pregabalin significantly alleviates pain in head and neck cancer patients with radiotherapy-related neuropathic pain. Neuropathic pain is an unavoidable treatment-related adverse event in patients undergoing radiotherapy. Pregabalin is extensively used in the management of neuropathic pain of other origins such as diabetes, chemotherapy, and post-herpetic neuralgia. However, its efficacy in treating radiotherapy-related neuropathic pain has not been examined.
Therefore, the team of researchers in the present study aimed to evaluate the efficacy and safety of pregabalin in the treatment of radiotherapy-related neuropathic pain. A total of 128 head and neck cancer patients with radiotherapy-related neuropathic pain were randomly assigned to receive either Pregabalin or placebo for 16 weeks. In the pregabalin group, 38…
