The role of prophylactic postoperative antibiotics in uncomplicated endoscopic skull base surgery has been under debate for a long time. A recent evidence synthesis based on systematic reviews, meta-analyses, and clinical trials demonstrates a remarkably low incidence of postoperative infections, even without antibiotic coverage. Extended antibiotic courses showed minimal to no clinical benefit, while raising concerns of resistance, cost, and unnecessary exposure. The findings strongly argue against routine postoperative antibiotic use, recommending selective use only in high-risk cases.
To read the full article and evaluate the data shaping future ENT practice, click here. Are we relying on tradition rather than evidence when prescribing antibiotics after skull base surgery? What criteria should truly guide our decision-making?
