A new epoch for patients requiring anticoagulation has arrived since several years. The approval of new target specific anticoagulants offers practitioners several advantages over traditionally used vitamin K antagonist agents including predictable pharmacokinetics, rapid onset of action, comparable efficacy and safety, all without the need for routine monitoring. This article tries to overviews about the recently approved prothrombin complex substrate used in life-threatening bleeding or who require emergent surgery.
The management of life-threatening hemorrhagic complicates is inevitable with any anticoagulation treatment. In a setting of therapy with vitamin K antagonists, the reversal of anticoagulant effects can be achieved by administering vitamin K and fresh-frozen plasma (FFP). One of the major disadvantages of the anticoagulants is a lack of specific antidotes or reversal…
