The recent strategies to develop ideal anesthetics are predominantly focused on modifying the structures of present drugs such as midazolam, propofol, and etomidate to improve their pharmacodynamic and pharmacokinetic characteristics. This article details about the novel anesthetics that are currently under development and have significant potential. Drugs presently under development using this rational design approach include analogs such as remimazolam, PF0713, and cyclopropyl methoxycarbonyl-etomidate . Ideal Characteristics of Anesthetic Drugs: Provide anesthesia and/or sedation with rapid onset of action and recovery.
Adverse effects, such as respiratory and cardiovascular depression, nausea, vomiting, and pain on injection would be insignificant. Retain a high therapeutic index Easy to formulate in an aqueous solution. Midazolam and propofol are among the most frequently used…
