Infection with herpes simplex virus 1 (HSV1), called herpes simplex labialis (HSL), is a continuing global public health problem for which various forms of treatment have had minimal impact. The most common form of infection with this virus, primary gingivostomatitis (the precursor of recurrent HSL infection), usually occurs in preschool or kindergarten children, adolescents and young adults, and does not recur in the same form. However, recurrences of HSL manifesting as cold sores can continue throughout adulthood. After primary infection the virus remains dormant in ganglion.
The dormant virus then awaits a “trigger” to reactivate it. The occasional recurrent HSL lesion does not have a serious impact on the health of a patient whose immune system is normal, and the patient should allow the lesion to run its course or use an over-the-counter remedy. However, for patients with altered…
