Key Takeaways: - Tongue cancer in young adults has distinct spatial transcriptomic features and molecular mechanisms compared to older patients. - Early-onset tongue cancer is characterized by downregulated oxidative phosphorylation and upregulated glycolysis. - The MAPK pathway plays a key role in the pathogenesis of tongue cancer in young adults. Summary: This study investigates the molecular mechanisms and spatial transcriptomic features of early-onset tongue cancer compared to older patients.
The classic risk factors for head and neck tumors, such as tobacco, alcohol, and human papillomavirus, are not associated with early-onset tongue cancer. The study found that early-onset tongue cancer is characterized by downregulated oxidative phosphorylation and upregulated glycolysis. The MAPK pathway was identified as a key player in the development of tongue cancer in young adults. The…
