Healing of the fracture is a multifactorial metabolic process and if impaired, results in fracture nonunion. Currently, there are a plethora of different strategies to augment the impaired bone-regeneration process. This article describes recent advances regarding the biologic enhancers of bone repair that play a critical role in the healing of fracture nonunion. Successful fracture healing requires mechanical stability and a viable biologic microenvironment.
However, fractures with compromised biology might benefit from treatment options that can augment the biologic potential at the site of bone repair. Regenerative strategies like the use of bone morphogenic proteins, platelet rich plasma, stem cells and anabolic agents are promising in the treatment of fractures either acute or fracture non-union. Bone grafting and bone substitutes Autologous bone graft is a commonly performed…
