It has been well established that combining pharmacologic agents with different mechanisms of action may produce either an enhanced effect or may induce the same effect at lower doses of each agent. Combination therapy may be administered as two agents initiated together or as one followed by another. This article will present few example of the combinatorial therapy and their effectiveness in treating pulmonary arterial hypertension (PAH). Pulmonary arterial hypertension is a rare lung disorder in which the arteries that carry blood from the heart to the lungs become narrowed, making it difficult for blood to flow through the vessels.
As a result, the blood pressure in these arteries -- called pulmonary arteries -- rises far above normal levels. This abnormally high pressure strains the right ventricle of the heart, causing it to expand in size. Overworked and enlarged, the right…
