Ketamine is an N-methyl-D-aspartate (NMDA) receptor blocking agent and a dissociative anesthetic with neurostimulatory side effects. In recent years, however, multiple research findings have favored the use of ketamine as a strong analgesic used in subanesthetic intravenous doses, and as a sedative. This article discusses in detail the role of ketamine for analgesia in adults and children.
Despite advances in technology including continuous peripheral nerve catheters and ultrasound guided nerve blocks, more than 80% of patients report inadequate pain control resulting in persistent postoperative pain, extended hospital stays and impaired rehabilitation. Furthermore, overtreatment may result in adverse events associated with excessive analgesic usage including increased morbidity and mortality. Nowadays, a primary concern and challenge for patients and physicians is an adequate…
