Researchers from the McMaster University, Hamilton, have recently discovered an association between Crohn’s disease (CD), an inflammatory bowel disease (IBD); autophagy, a catabolic process to provide energy; and serotonin, a signaling molecule. This study is published in the journal Science Advances. Study design A case-control study Colonic biopsy and blood samples from the experimental group with CD and the healthy control group of 18 participants each were analyzed.
A mouse model of IBD was also studied. Study participants A total of 36 human participants were included in the study. Mouse model - 8 to 12 mice with IBD Key findings Experimental group with CD: o Higher plasma serotonin levels o Autophagy dysfunction Healthy control group: o Normal plasma serotonin levels o Normal autophagy Mouse Model – High levels of serotonin Conclusion The results of this study…
