The recently collaborated Comparing Outcomes of Antibiotic Drugs and Appendectomy (CODA) trial findings, which assessed antibiotics and appendectomy for treating appendicitis, were published in the New England Journal of Medicine. The CODA trial is the largest-ever study of appendicitis treatment, which included 25 hospitals across 14 states of the US. Study design Randomized control trial Participants were divided into two groups, either receiving antibiotics or an appendectomy as treatment.
Study participants A total of 1552 appendicitis patients Key findings Antibiotic group: At the end of the first three months, 7 out of 10 patients could elude an appendectomy. By the end of four years, less than 50% of participants in the antibiotic group underwent appendectomy. Appendectomy: Appendicolith posed as a complication in 25% of acute cases and implicated the need for appendectomy in the…
