Acute pyelonephritis is a life-threatening infection with significant risk of renal failure. The infiltration of the bacterial pathogen to renal parenchyma originates from the lower urinary tract or the bloodstream. Early manifestations are non-specific, like fever, pain/tenderness, nausea, and vomiting.
Other symptoms such as gross hematuria is a less frequent occurrence in men but occur in 30-40% women affected by acute pyelonephritis. And hence, a rigorous antibiotic regimen is required. Outpatient Therapy First Line Treatment 500 mg oral Ciprofloxacin twice daily for 7 days OR 100 mg extended-release oral Ciprofloxacin for 7 days OR 750 mg oral Levofloxacin for 5 days In case of perceived resistance to Fluoroquinolone is >10%, a single dose of 1g IV Ceftriaxone or consolidated 24-hour dose of 7mg/kg IV Gentamycin or 7mg/kg IV Tobramycin or 20mg/kg IV Amikacin should be…
