A 38-year-old woman was presented with a rash which developed in last 24 hours and spread across the body. History She was detected with peripheral T-cell non-Hodgkin’s lymphoma stage 3A. She had undergone six cycles of CHOP-21 chemotherapy; however, PET scan revealed residual disease in her mediastinal lymph nodes. During a planned admission for a BEAM autologous stem cell transplantation, she developed a widespread, mildly pruritic skin eruption 4 days after receiving pre-conditioning antimicrobials (azithromycin, penicillin, fluconazole, and acyclovir). Examination There were multiple erythematous macules and papules scattered diffusely across her limbs and trunk.
There were no pustules, blisters or scaling. The eruption blanched on pressure. Skin Biopsy revealed, a dense perivascular infiltrate of lymphocytes and eosinophils around the upper dermal blood vessels. C-reactive protein…
