A 46-year-old woman had a routine screening mammogram that showed new calcifications in the posterior left breast. A diagnostic mammogram showed several small punctate calcifications, and a 6-month interval follow-up was recommended. The follow-up mammogram showed pleomorphic calcifications spanning 1.5 cm (Figure attached). Three sites of calcifications were biopsied. The posterior site showed high–nuclear grade ductal carcinoma in situ (DCIS) with comedonecrosis.
The DCIS specimen stained positive for estrogen receptor (3+, 90%) and progesterone receptor (3+, 75%). The patient underwent genetic counseling and testing. No known mutations were found, but four variants of uncertain significance were identified in the APC gene. What are the next steps in management for this patient? *This case is from Docplexus editorial team for educative purpose only Source: Cancer Network Stay…
