Genome sequencing has played an important role in understanding various SARS-CoV-2 variants and vaccine development. A large dataset of SARS-CoV-2 genomes has been collected in the GISAID[VH1] [AM2] (A global initiative on sharing avian flu and coronavirus data) database having more than 3.7 million genome sequences from all over the globe. Researchers in Lithuania have studied the genetic lineage [AP3] of the most recently established variant. The variant lineage B.1.1.523, now reported in 27 countries, shows immune escape, mutations—156_158del, E484K, and S494P substitution in Spike (S) protein.
This study was conducted as a part of routine analysis of their general surveillance testing. Research details Lineage assignment tool pangolin 3.1.11 was used to assign lineages. Phylogenetic analysis was done to identify the origin and transmission of the variant. Genomic or protein…
