Immuno-modulation is an essential feature of pregnancy processes. Inflammatory pathways regulate the early embryonic adhesion, fetal survival, and delivery. This article aims to discuss the significant immunological changes at different stages of pregnancy. Immunological changes do occur during different stages of pregnancy including implantation & placentation, fetal development, and parturition. For a successful pregnancy, the maternal system must adapt to the continuously changing immunological scenarios.
Studies have clearly established the role of inflammatory pathways in pregnancy outcomes. A pro-inflammatory stage of implantation and placentation A breakdown & restructuring of decidua occurs when blastocyst attaches to the uterine lining during implantation and placentation. This resembles tissue injury & repair and triggers inflammatory pathway. Pro-inflammatory molecules at…
