PPI medicines are written excessively to old persons to cover analgesic taken by them for control of pain but using these PPI is very dangerous. As per study reported in the journal Osteoporosis International, proton pump inhibitors (PPIs) are significantly associated with an increased risk of hip fracture. This effect is not seen with histamine 2 receptor antagonists (H2RAs). The meta-analysis included 24 observational studies with 2,103,800 participants.
Of these, 319,568 were hip fracture patients. Analysis showed that patients on PPIs had a greater risk of hip fracture than those who were not on PPI (risk ratio 1.20; p < 0.0001). The risk increased with the dose of PPIs. The observed risk was high for both low and medium doses of PPIs and it was even greater for patients taking high dose PPIs; low dose RR 1.17 (p = 0.002); medium dose RR 1.28 (p <0.0001) and higher dose RR 1.30 (p…
