The presence of granular tissue in the middle ear results from the rupture of the basement membrane of the epithelial cell lining in the middle ear. It may occur due to bacterial toxins, the release of inflammatory mediators from ruptured liposomes, and the accumulation of subepithelial fluid and vacuoles. The granular tissue exerts pressure on the epithelium, thus affecting its function. Furthermore, the tissue may progress and exert pressure on the tympanic membrane, thus forming perforations.
Under severe cases, this may lead to the medial displacement of the eardrum, exposing the posterosuperior quadrant of the tympanic membrane to the venturi effect in the isthmus tympanic posticous, forming retraction pockets. Which of the following conditions is associated with granulation of tissue and a retraction pocket in the posterosuperior quadrant of the tympanic membrane? Sensorineural…
