Psoriasis vulgaris is the most prevalent skin disorder and is associated with autoimmune reactions. It is characterized by the presence of inflamed and raised plaques. They constantly shed scales due to the excessive growth of skin epithelial cells. Psoriasis is associated with: Hyperplasia of epidermal keratinocytes Vascular hyperplasia and ectasia Infiltration of T-lymphocytes, neutrophils, and other types of leucocytes in the affected skin Pathogenesis of psoriasis mainly involves a T-lymphocyte-mediated autoimmune response and thus can be managed by targeting these cells.
Also, it can be managed by targeting cellular and molecular pathways of inflammation that contribute to disease pathogenesis. Which of the following is/are TRUE about the pathogenesis of psoriasis? Alefacept, a fusion protein binds to CD2 on T-lymphocytes. Inflammatory cytokines such as tumor necrosis factor (TNF)…
