A 65-year-old man presented with generalized itching and redness of his skin for 1 month, with severe keratosis on the soles of his feet and the palms of his hands. Physical examination From the physical examination, characteristic exfoliative dermatitis with bilateral axillary lymphadenopathy but no hepatosplenomegaly was found. Clinical Investigation Hemoglobin was normal (139g/l) Raised white-cell count (12.8 x 10 9 /l). The blood film showed an increase of small cleaved lymphocytes, 90% of which were T lymphocytes.
Surface membrane immunoglobulin results were presented below: Kappa 1% Lambda 2% Mu 2% Gamma 0% Alpha 0% CD3 92% CD19 2% CD5 0% Electron microscopy of buffy coat cells showed that the nuclei of these cells had multiple clefts, an appearance characteristic of cells known as Sézary cells. What is the probable diagnosis? Click here for the answer *This patient case is…
