A 14-year-old girl was diagnosed with common variable immunodeficiency (CVID) at two years of age. She had suffered from a respiratory arrest following neonatal pneumonia and from recurrent episodes of stridor, pneumonia, and wheezing. At six years, she had a further illness requiring ventilation. Immunological tests Total serum IgG level (2.5 g/L) - Reduced Low IgG2 (0.26 g/L), IgG3 (<0.17g/L) and IgG4 (<0.37 g/L) subclasses, low IgA (<0.4 g/L) and a normal IgM level (0.6 g/L).
Inadequate antibody response to childhood immunizations Normal CD40 expression, normal lymphocyte subsets Normal percentage of memory B cells (19.03 %) and class switch memory B cells (9.36 %) An immunoglobulin replacement therapy was initiated. Except for an episode of chickenpox a few years later, she remained healthy. Years later, she presented with generalized joint pains, although no joint swelling was…
