Preoperative oral carbohydrate loading is known to reduce postoperative insulin resistance, but its use in patients with type 2 diabetes mellitus (T2DM) remains controversial due to concerns about glycemic instability. To explore a safer alternative, a study evaluated the effects of preoperative oral isomaltulose, a low–glycemic index carbohydrate, on postoperative insulin resistance and glycemic variability in T2DM patients undergoing elective laparoscopic non-gastrointestinal surgery, involving 60 participants. The study found that preoperative oral isomaltulose significantly reduced postoperative insulin resistance compared with control, with lower homeostasis model assessment (HOMA-IR) values (6.89 vs. 11.60) and reduced serum insulin levels (15.59 vs.
24.54) at 24 hours postoperatively. Although median blood glucose levels were slightly higher (155.70 vs. 144.00 mg/dL), glycemic…
