Angiotensin-converting enzyme (ACE) inhibitors are a first-line option for treating high blood pressure, heart failure, and diabetic kidney disease. However, their use is associated with a risk of acute angioedema- a rare and potentially life-threatening condition. So far, no treatment options for ACE-induced angioedema have been reported to be reliably effective, and therefore, the research for effective therapeutic continues.
The increasing use of ACE inhibitors is resulting in a comparatively large number of patients at risk for associated angioedema that accounts for one-third case of angioedema treated in the emergency room. Standard emergency room treatment of ACE inhibitor-induced angioedema consists of symptomatic treatment with glucocorticoids and antihistamines. However, this form of angioedema is not a histamine-mediated reaction, and thus patients generally do not have a…
