The article address why medical and lifestyle interventions during pregnancy have failed to improve perinatal outcomes in obese women and discusses the potential mechanisms by which maternal obesity in pregnancy propagates the vicious cycle of obesity throughout the life. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies.
Metabolically, obese women have increased insulin resistance in early pregnancy, which manifests clinically in late gestation as glucose intolerance and fetal overgrowth. Prevalence In 2000, WHO noted that obesity “is now so common that it is replacing the more traditional public health concerns , including undernutrition and infectious disease, as one of the most significant contributors to ill health.” In Europe, WHO estimates that more than 50% of men and women are overweight or obese and…
