Anaplastic thyroid carcinoma (ATC) is a poorly differentiated thyroid cancer. It cannot uptake iodine or synthesise thyroglobulin. Molecular analyses of ATC tumours have yielded interesting results, which could help in understanding the underlying mechanisms of this aggressive disease process. Managing ATC can be challenging and includes rapid diagnosis, adequate staging, and interdisciplinary, multimodal treatments to optimise patient outcome.
This article outlines the diagnosis and management approach for anaplastic thyroid carcinoma Anaplastic thyroid cancers are undifferentiated tumours of the thyroid follicular epithelium. In contrast to differentiated thyroid cancers, these cancers are extremely aggressive, with a disease-specific mortality. Early recognition of the disease is essential to allow prompt initiation of therapy. Anaplastic thyroid cancer (ATC) occurs in less than 2%…
