Sotos syndrome (cerebral gigantism), first described in 1964 by Juan Sotos, is an uncommon hereditary condition causing abnormal physical growth during childhood. Children with Sotos syndrome are often larger at birth, taller, and have larger skulls (macrocrania) than their peers. In about 75 to 85% of patients, advanced bone aging is observed.
Symptoms differ from person to person and include: An excessively huge head, with a somewhat protruding forehead and pointed chin, and large hands and feet. Down-slanting eyes Hypertelorism (abnormally enlarged distance between the eyes) Hypotonia (low muscle tone) and lax joints Sotos syndrome and several other clinical diseases share phenotypic similarities. Weaver syndrome, Bannayan–Riley–Ruvalcaba syndrome, Beckwith–Wiedemann syndrome, and benign familial macrocephaly are the four disorders that are most frequently confused with Sotos…
