Antibiotic-resistant bacterial pneumonia poses a serious health threat worldwide. It is evident that immunity-stimulating agents and treatments often assist the body to kill the bacteria, but associated inflammation resulting in lung tissue damage raises the concern about their use. A recent finding in the Science Translational Medicine has revealed an approach that provides pleiotropic benefits such as enhanced bacterial killing and reduced lung damage. Neutrophils get activated by the immune system as bacteria invents infection in the body.
The immune system triggered neutrophils act at the infection site and kills the infectious bacteria. However, the release of inflammatory compounds by neutrophils damages the lung tissues. According to researchers, an enzyme IP6K inhibits the signaling by PIP3 molecule in the neutrophil. Moreover, finding suggested that inhibition of IP6K in a…
