Highlights Lipid-based nanoemulsion addresses both tear instability and evaporation Effective across DED subtypes, especially evaporative and mixed disease Dry eye disease (DED) is a multifactorial ocular surface disorder characterized by tear film instability, hyperosmolarity, inflammation, and neurosensory abnormalities. Increasing evidence indicates that evaporative mechanisms and meibomian gland dysfunction (MGD) play a central role in the majority of patients, either alone or in combination with aqueous deficiency.
Conventional aqueous eye drops , while effective for short-term hydration, do not address tear film lipid layer disruption a key contributor to tear evaporation and symptom persistence. 1 Recent multicenter clinical trials evaluating propylene glycol hydroxypropyl guar (PG-HPG) lipid-based nanoemulsion eye drops (Systane® COMPLETE) provide mechanistic and clinical…
