Sealing initial non-cavitated carious lesions in adults has been increasingly recommended to prevent lesion progression; however, evidence regarding the effectiveness of different sealant materials remains limited. To address this gap, the present study investigated the use of a bioactive fissure sealant with SmartCap technology compared with a fluoride-releasing fissure sealant, evaluating their retention and ability to inhibit lesion progression in 36 adult patients with non-cavitated occlusal carious lesions. Over a median period of 24 months, the study found that biocoat sealants demonstrated superior clinical performance compared with Clinpro, with a higher success rate (93.75% vs.
65.62%) and fewer failures due to loss of retention or caries progression (2 vs. 11 sealants). Intergroup analysis using the Chi-square test revealed a significantly lower risk of failure with Biocoat…
