Blau syndrome is a chronic, progressive illness with a broad and frequently unpredictable severity range. The initial symptom of Blau syndrome is generally a skin rash, which occurs on the face even at one month of age and subsequently spreads to the trunk. Patients may experience recurrent bouts of skin lesions that clear on their own. Symptoms on joints commonly appear before the age of ten, with painless cyst-like swellings on the backs of the feet and wrists. Symmetric arthritis develops in the wrists, ankles, knees, and elbows.
As the condition advances, camptodactyly owing to hypertrophic tenosynovitis is frequently documented. The majority of patients do not encounter severe impairment until they are in their 40s or 50s. Granulomatous iridocyclitis and posterior uveitis can develop into severe destructive panuveitis in the blink of an eye. Life expectancy may be shortened in…
